The Usefulness of F-18 FDG PET/CT-mammography for Preoperative Staging of Breast Cancer: Comparison with Conventional PET/CT and MR-mammography

  • Eun-ha Moon Soonchunhyang university hospital

Abstract

Purpose: The objective of this study was to compare the diagnostic efficacy of an integrated Fluorine-18 fluorodeoxyglucose (F-18 FDG) PET/CT-mammography (mammo-PET/CT) with conventional torso PET/CT (supine-PET/CT) and MR-mammography for initial assessment of breast cancer patients. Materials and Methods: Forty women (52.0 ± 12.0 years) with breast cancer who underwent supine-PET/CT, mammo-PET/CT, and MR-mammography from April 2009 to August 2009 were enrolled in this study. We compared the size of the tumor, tumor to chest wall distance, tumor to skin distance, volume of axillary fossa, and number of metastatic axillary lymph nodes between supine-PET/CT and mammo-PET/CT. Next, we assessed the difference of focality of primary breast tumor and tumor size in mammo-PET/CT and MR-mammography. Histopathologic findings served as the standard of reference. Results: In the comparison between supine-PET/CT and mammo-PET/CT, significant differences were found in the tumor size (supine-PET/CT: 1.3 ± 0.6 cm, mammo-PET/CT: 1.5 ± 0.6 cm, p<0.001), tumor to thoracic wall distance (1.8 ± 0.9 cm, 2.2 ± 2.1 cm, p<0.001), and tumor to skin distance (1.5 ± 0.8 cm, 2.1 ± 1.4 cm, p<0.001). The volume of axillary fossa was significantly wider in mammo-PET/CT than supine-PET/CT (21.7 ± 8.7 cm3 vs 23.4 ± 10.4 cm3, p=0.03). Mammo-PET/CT provided more correct definition of the T-stage of the primary tumor than did supine-PET/CT (72.5% vs. 67.5%). No significant difference was found in the number of metastatic axillary lymph nodes. Compared with MR-mammography, mammo-PET/CT provided more correct classification of the focality of lesion than did MR-mammography (95% vs. 90%). In the T-stage, 72.5% of cases with mammo-PET/CT and 70% of cases with MR-mammography showed correspondence with pathologic results. Conclusion: Mammo-PET/CT provided more correct definition of the T-stage and evaluation of axillary fossa may also be delineated more clearly than with supine-PET/CT. The initial assessment of mammo-PET/CT would indicate similar accuracy to MR-mammography for decision of focality and T-stage of primary breast tumor.
Published
2013-10-23
How to Cite
Moon, E.- ha. (2013). The Usefulness of F-18 FDG PET/CT-mammography for Preoperative Staging of Breast Cancer: Comparison with Conventional PET/CT and MR-mammography. Radiology and Oncology, 47(4). Retrieved from https://radioloncol.com/index.php/ro/article/view/1102
Section
Nuclear medicine