Role of contrast-enhanced ultrasound in evaluating the efficiency of ultrasound guided percutaneous microwave ablation in patients with renal cell carcinoma

  • Xin Li 1 Interventional Ultrasound Department of Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China 2 Medical College of Nankai University, 94 Weijin Road, Tianjin300071, China
  • Ping Liang 1 Interventional Ultrasound Department of Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China
  • Jie Yu 1 Interventional Ultrasound Department of Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China
  • Xiao-ling Yu 1 Interventional Ultrasound Department of Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China
  • Fang-yi Liu 1 Interventional Ultrasound Department of Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China
  • zhi-gang Cheng 1 Interventional Ultrasound Department of Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China
  • Zhi-yu Han 1 Interventional Ultrasound Department of Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China

Abstract

Abstract

Objective: To evaluate the efficiency and feasibility of contrast-enhanced ultrasound (CEUS) in assessing of renal cell carcinomas (RCCs) following US-guided percutaneous microwave ablation (MWA).

Materials and Methods The CEUS results of the third day after ablation were compared with biopsy results and contrast-enhanced CT/MRI results simultaneously. The follow-up was administrated by CEUS and CT/MRI at 1, 3, 6 months and every 6 months subsequently. Combination of the clinical follow-up results and CT/MRI imaging results were reference standard of CEUS results for the long-term therapeutic effect.

Results: Eighty-three lesions with diameter 3.2±1.6cm (rang 0.6-7.8cm) were ablated. On the third day after MWA, CEUS showed 68 of 83 (81.9%) were successfully ablated and confirmed by 72 hours contrast-enhanced CT/MRI after MWA. Fifteen of 83(18.1%) appeared residual tumor on CEUS, then were performed biopsy and CEUS-guided ablation. Among 15 patients, 13 (86.7%) were verified with residual tumor by biopsy results. The sensitivity, specificity, accuracy, positive and negative predictive value were 100%, 97.1%, 97.6%, 86.7% and 100%, respectively. Seventy-six patients survived in the follow-up ranged from 3 to 74 (median 26) months. During the follow-up, the CEUS showed local recurrence in 7 patients, and six of them achieved consistent results on CEUS and CT/MRI imaging. The sensitivity, specificity, accuracy, positive and negative predictive value for detecting recurrence tumor were 85.7%, 98.7%, 97.6%, 85.7% and 98.7%, respectively.

Conclusion The post-procedural CEUS was demonstrated an efficient and feasible method in evaluating therapeutic effect of RCCs following MWA.

Author Biographies

Xin Li, 1 Interventional Ultrasound Department of Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China 2 Medical College of Nankai University, 94 Weijin Road, Tianjin300071, China
1 Department of Interventional Ultrasound
PLA General Hospital
2 Medical College of Nankai University
Ping Liang, 1 Interventional Ultrasound Department of Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China
1 Department of Interventional Ultrasound
PLA General Hospital
Jie Yu, 1 Interventional Ultrasound Department of Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China
1 Department of Interventional Ultrasound
PLA General Hospital
Xiao-ling Yu, 1 Interventional Ultrasound Department of Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China
1 Department of Interventional Ultrasound
PLA General Hospital
Fang-yi Liu, 1 Interventional Ultrasound Department of Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China
1 Department of Interventional Ultrasound
PLA General Hospital
zhi-gang Cheng, 1 Interventional Ultrasound Department of Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China
1 Department of Interventional Ultrasound
PLA General Hospital
Zhi-yu Han, 1 Interventional Ultrasound Department of Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China
1 Department of Interventional Ultrasound
PLA General Hospital
Published
2013-10-23
How to Cite
Li, X., Liang, P., Yu, J., Yu, X.- ling, Liu, F.- yi, Cheng, zhi- gang, & Han, Z.- yu. (2013). Role of contrast-enhanced ultrasound in evaluating the efficiency of ultrasound guided percutaneous microwave ablation in patients with renal cell carcinoma. Radiology and Oncology, 47(4). Retrieved from https://radioloncol.com/index.php/ro/article/view/1476
Section
Radiology