Dual time point imaging fluorine-18 flourodeoxyglucose positron emission tomography for evaluation of large loco-regional recurrences of breast cancer treated with electrochemotherapy

  • Louise Wichmann Matthiessen Copenhagen University Hospital Herlev
  • Helle Hjorth Johannesen Copenhagen University Hospital Herlev
  • Kristin Skougaard Copenhagen University Hospital Herlev
  • Julie Gehl Copenhagen University Hospital Herlev
  • Helle Westergren Hendel Copenhagen University Hospital Herlev

Abstract

Electrochemotherapy is a local anticancer treatment very efficient for treatment of small cutaneous metastases. The method is now being investigated for large cutaneous recurrences of breast cancer that are often confluent masses of malignant tumour with various degrees of inflammation. To this end 18-Flourine-Flourodeoxyglucose-Positron Emission Tomography/Computed Tomography (FDG-PET/CT) could be a method for response evaluation. However, a standard FDG-PET/CT scan can not differentiate inflammatory tissue from malignant tissue. Dual point time imaging (DTPI) FDG-PET has the potential of doing so. The purpose of this study was to investigate if DTPI FDG-PET/CT could assess response to electrochemotherapy and to assess the optimal timing of imaging.

Within a phase II clinical trial 11 patients with cutaneous recurrences had  FDG-PET/CT scans at three time points: 60 min, 120 min and 180 min after FDG injection. The scans were performed before and 3 weeks after electrochemotherapy.

A significant reduction in maximum standard uptake value at 60 min post injection was seen after treatment. Furthermore a change in the FDG uptake pattern was observed; from increasing uptake in up to 180 min post injection before treatment to stabilization of FDG uptake at 120 min post injection after treatment. The change in FDG uptake pattern over time lead to change of response in three target lesions; two lesions changed from stable metabolic disease to partial metabolic response and one lesion changed from partial metabolic response to stable metabolic disease. To ensure detection of the change in uptake pattern, scanning 60 and 180 min post injection seems optimal.

The present study shows that FDG-PET/CT 60 and 180 min after tracer injection is a promising tool for response evaluation of cutaneous recurrences of breast cancer treated with electrochemotherapy.

Author Biographies

Louise Wichmann Matthiessen, Copenhagen University Hospital Herlev
Department of Oncology
Helle Hjorth Johannesen, Copenhagen University Hospital Herlev
Department of Radiology
Kristin Skougaard, Copenhagen University Hospital Herlev
Department of Oncology
Julie Gehl, Copenhagen University Hospital Herlev
Center for Experimental Drug and Gene Electrotransfer (C*EDGE), Department of Oncology
Helle Westergren Hendel, Copenhagen University Hospital Herlev
Department of Clinical Physiology and Nuclear Medicine
Published
2013-10-23
How to Cite
Matthiessen, L. W., Johannesen, H. H., Skougaard, K., Gehl, J., & Hendel, H. W. (2013). Dual time point imaging fluorine-18 flourodeoxyglucose positron emission tomography for evaluation of large loco-regional recurrences of breast cancer treated with electrochemotherapy. Radiology and Oncology, 47(4). Retrieved from https://radioloncol.com/index.php/ro/article/view/1705
Section
Nuclear medicine