Inter-application displacement of brachytherapy dose received by the bladder and rectum of the patients with inoperable cervical cancer

  • Goran Marosevic International Medical Centers Banja Luka
  • Dzenita Ljuca University Clinical Center Tuzla
  • Hasan Osmic University Clinical Center Tuzla
  • Semir Fazlic University Clinical Center Tuzla
  • Oliver Arsovski International Medical Centers Banja Luka
  • Dusan Mileusnic Military Medical Academy Belgrade

Abstract

Aim. To examine on the CT basis the inter-application displacement of the positions D0,1cc, D1cc and D2cc of the brachytherapy dose applied to the bladder and rectum of the patients with inoperable cervical cancer.

Methods. This prospective study included 30 patients with cervical cancer who were treated by concomitant chemo-radiotherapy. HDR intracavitary brachytherapy was made by the applicators type Fletcher tandem and ovoids. For each brachytherapy application the position D0,1cc  was determined of the bladder and rectum that receive a brachytherapty dose. Then, based on the X, Y, and Z axis displacement, inter-application mean X, Y, and Z axis displacements were calculated as well as their displacement vectors (R). It has been analyzed whether there is statistically significant difference in inter-application displacement of the position of the brachytherapy dose D0,1cc, D1cc and D2cc of the bladder and rectum. The ANOVA test and post-hoc analysis by Tukey method were used for testing statistical importance of differences among the groups analyzed. The difference among the groups analyzed  was considered significant if P<0.05

Results. There are significant inter-application displacements of the position of the brachytherapy dose D0,1cc, D1cc and D2cc of the bladder and rectum.

Conclusions. When we calculate the cumulative brachytherapy dose by summing up D0,1cc, D1cc and D2cc of the organs at risk for all the applications, we must bear in mind their inter-application displacement, and the fact that it is less likely that the worst scenario would indeed happen.

Key words: inter-application variations, brachytherapy, inoperable cervical cancer

Author Biographies

Goran Marosevic, International Medical Centers Banja Luka
Center for radiotherapy
Dzenita Ljuca, University Clinical Center Tuzla
Gynaecology and Obsterics Clinic
Hasan Osmic, University Clinical Center Tuzla
Department for radiotherapy
Semir Fazlic, University Clinical Center Tuzla
Department for radiotherapy
Oliver Arsovski, International Medical Centers Banja Luka
Center for radiotherapy
Dusan Mileusnic, Military Medical Academy Belgrade
Department for radiotherapy
Published
2014-05-09
How to Cite
Marosevic, G., Ljuca, D., Osmic, H., Fazlic, S., Arsovski, O., & Mileusnic, D. (2014). Inter-application displacement of brachytherapy dose received by the bladder and rectum of the patients with inoperable cervical cancer. Radiology and Oncology, 48(2). Retrieved from https://radioloncol.com/index.php/ro/article/view/1817
Section
Clinical oncology