ELECTROCHEMOTHERAPY AS A NEW THERAPEUTIC STRATEGY IN ADVANCED MERKEL CELL CARCINOMA OF HEAD & NECK REGION: CASE REPORT.
Merkel Cell Carcinoma (MCC) is a rare and aggressive tumor, arising from a cutaneous mechanoceptor cell located in the basal layer of epidermis, with poor prognosis. The treatment of choice for the initial stage of the disease is surgery and/or radiotherapy . The treatment of recurrent or advanced disease is still controversial.
We report a case of 84 years old woman affected by a recurrent MCC of the chin treated with multiple sessions of electrochemotherapy (ECT).
ECT is a tumor ablation modality providing delivery into cell interior of impermeant or poorly permeant chemotherapeutic drugs such as cisplatin and bleomycin. A locally applied electrical field enhances the membrane permeability allowing intracellular accumulation of the chemotherapeutic agent.
We treated the patient with four session of ECT in a period of 20 months with an objective response of the lesion and good quality of residual life.
Our case shows the effectiveness of ECT in the local control of an advanced MCC of the head and neck region in patient not suitable for standard therapeutical options, improving his prognosis and quality of life.