Primary pulmonary choriocarcinoma - literature review; gestational event determines better survival

  • Ziga Snoj University Medical Centre
  • Erik Škof
  • Igor Kocijančič Prof. Igor Kocijančič, MD PhD

Abstract

Aim: To establish whether there are different clinical entities of primary pulmonary choriocarcinoma (PPC) that deserve different diagnostic approach and the most optimal treatment of PPC.

Patients and methods: A systematic review with PubMed search was conducted to identify studies that reported cases of PPC.

Results: Women with history of gestational event showed better survival outcome than women without the history of gestational event (p=0,040). Patients treated with combination of surgery and chemotherapy survived longer than the patients without combination of surgery and chemotherapty (p=0,010). Futhermore, multivariate analysis of prognostic factors showed that the treatment combining surgery with chemotherapy had independent prognostic significance (p=0,031).

Conclusion: PPC is an extreme rarity with variable clinical characteristics and outcome. Women with history of gestational event showed better survival, therefore genetic examination of PPC can help us to predict patient’s prognosis. Surgery followed by adjuvant chemotherapy appears to represent the best treatment for PPC.

Author Biographies

Ziga Snoj, University Medical Centre

Resident

Radiology Institute

Zaloška 2, 1000 Ljubljana, Slovenia

 

Erik Škof
Erik Škof, MD PhD: Institute of Oncology
Igor Kocijančič, Prof. Igor Kocijančič, MD PhD
Radiology Department, University Medical Centre
Published
2017-02-28
How to Cite
Snoj, Z., Škof, E., & Kocijančič, I. (2017). Primary pulmonary choriocarcinoma - literature review; gestational event determines better survival. Radiology and Oncology, 51(1). Retrieved from https://radioloncol.com/index.php/ro/article/view/2359
Section
Review