F-18 FDG-PET/CT parameters as predictors of outcome in non surgical NSCLC patients.

  • Antonio Nappi
  • Rosj Gallicchio
  • Vittorio Simeon
  • Anna Nardelli
  • Alessandra Pelagalli
  • Angela Zupa
  • Giulia Vita
  • Angela Venetucci
  • Michele Di Cosola
  • Francesco Barbato
  • Giovanni Storto IRCCS CROB Rionero in Vulture, Italy

Abstract

Purpose: we evaluated the prognostic significance of standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) on [F-18]FDG PET/CT in patients with non-surgical non-small-cell lung cancer (NSCLC). Material and Methods: 103 patients (mean age, 65,6±16 years) underwent [F-18]FDG PET/CT before the chemotherapy. The SUVmax value, the MTV (cm3; 42% threshold) and the TLG (g) were registered. The patients were followed up 18 months thereafter (range 12-55 months). Main events such as failure to respond without progression, progression and/or disease-related death constituted surrogate end-points. The optimal SUVmax, MTV and TLG cut-off to predict the patients' outcome was estimated. PET/CT results were then related to disease outcome (progression free survival; PFS). Results: the Kaplan-Meier survival analysis for SUVmax showed a significant better PFS in patients presenting lower values as compared to those having higher (p <0.05, log-rank test). MTV and TLG were not suitable for predicting PFS apart from the subset with mediastinal nodal involvement. Conclusions: despite the availability of new tools for the quantitative assessment of disease activity on PET/CT the SUVmax rather than MTV and TLG remains the only predictor for PFS in NSCLC patients. MTV holds a value only when concomitant nodal involvement occurs.

Author Biographies

Antonio Nappi
Rosj Gallicchio
Vittorio Simeon
Anna Nardelli
Alessandra Pelagalli
Angela Zupa
Giulia Vita
Angela Venetucci
Michele Di Cosola
Francesco Barbato
Giovanni Storto, IRCCS CROB Rionero in Vulture, Italy
Nuclear Medicine dept, chief of dept.
Published
2016-01-11
How to Cite
Nappi, A., Gallicchio, R., Simeon, V., Nardelli, A., Pelagalli, A., Zupa, A., Vita, G., Venetucci, A., Di Cosola, M., Barbato, F., & Storto, G. (2016). F-18 FDG-PET/CT parameters as predictors of outcome in non surgical NSCLC patients. Radiology and Oncology, 49(4). Retrieved from https://radioloncol.com/index.php/ro/article/view/2401
Section
Nuclear medicine