The influence of the distal resection margin length on local recurrence and long- term survival in patients with rectal cancer after chemoradiotherapy and sphincter- preserving rectal resection

  • Jan Grosek University Medical Centre Ljubljana

Abstract

Introduction.  Low recurrence rates and long term survival are the main therapeutic goals of rectal cancer surgery. Complete, margin- negative resection confers the greatest chance for a cure. The aim of our study was to determine whether the length of the distal resection margin  was associated with local recurrence rate and long- term survival.

Matherials and methods. One hundred and nine patients, who underwent sphincter- preserving resection for locally advanced rectal cancer after preoperative chemoradiotherapy  between 2006 and 2010 in two Tertiary Referral Centres were included in the study. Distal resection margin lengths were measured on formalin- fixed, pinned specimens. Characteristics of patients with distal resection margin  < 8 mm (Group I, n = 27), 8 – 20 mm (Group II, n = 31) and > 20 mm (Group III, n = 51)  were retrospectively analysed and compared. Median (range) follow-up time in Group I was 89 (51 -111), in Group II 83 (57 – 111) and in Group III 80 (45 – 116) months (p = 0.326), respectively.

Results. Univariate survival analysis showed that distal resection margin  length was not statistically significantly associated with overall survival or local recurrence rate (p > 0.05). Even after adjusting for pathologic T and N stage (yT, yN), distal resection margin  length was still not statistically significantly associated with overall survival.

Conclusions. Our study shows that close distal resection margins  can be accepted as oncologically safe for sphincter- preserving rectal resections after preoperative chemoradiotherapy.

Keywords. Rectal cancer, distal resection margin, chemoradiotherapy,  local recurrence,  survival

Author Biography

Jan Grosek, University Medical Centre Ljubljana
Department of Abdominal Surgery
Published
2017-06-07
How to Cite
Grosek, J. (2017). The influence of the distal resection margin length on local recurrence and long- term survival in patients with rectal cancer after chemoradiotherapy and sphincter- preserving rectal resection. Radiology and Oncology, 51(2). Retrieved from https://radioloncol.com/index.php/ro/article/view/2561
Section
Clinical oncology