Metastatic Sebaceous cell carcinoma, review of the literature and use of electrochemotherapy as possible new treatment modality

Abstract

ABSTRACT

Background

Purpose Metastatic Extracutaneous sebaceous carcinoma is a rare event that could involve the head and neck. The treatment of choice for the initial stage of the disease is surgery and/or radiotherapy. The treatment of recurrent or advanced disease is still controversial.

Extensive literature search was done, and the treatment options are discussed.

Case report and review

We report a case of 85 years old man with a recurrend and locally metastatic extraorbital  sebaceous carcinoma of the scalp treated with electrochemotherapy. During the period of 8 months, two sessions of electrochemotherapy were employed, which resulted in an objective response of the tumour and good quality of life. Several treatment modalities are in use, however their effectiveness are limited.

A review of the literature has been performed for treatment with skin directed therapies for  Metastatic Extracutaneous sebaceous carcinoma, which indicated that new treatment options are needed. Based on this first experience we propose further studies on this rear entity of the tumor, and employ electrochemotherapy as a treatment of choice in clinical situations that needed a local control of this pathology when other radical options are not available or convenient.