Breast Dynamic Contrast Enhanced MRI: Fibrocystic Changes Presenting as a Non-Mass Enhancement Mimicking Malignancy

Abstract

Background. We aimed to analyze the morphokinetic features of breast fibrocystic changes (nonproliferative lesions, proliferative lesions without atypia and proliferative lesions with atypia) presenting as a non-mass enhancement (NME) in dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) examination.

Patients and methods. Forty-six patients with histologically proved fibrocystic changes (FCCs) were retrospectively reviewed, according to Breast Imaging Reporting and Data System (BI-RADS) lexicon. Prior to DCE-MRI examination, a unilateral breast lesion suspicious of malignancy was detected clinically, on mammography or breast ultrasonography.

Results. The predominant features of FCCs presenting as NME in DCE-MRI examination were: unilateral regional or diffuse distribution (in 35 patients or 76.1%), heterogeneous or clumped internal pattern of enhancement (in 36 patients or 78.3%), plateau time-intensity curve (in 25 patients or 54.3%), moderate or fast wash-in (in 31 patients or 67.4%). Nonproliferative lesions were found in 11 patients (23.9%), proliferative lesions without atypia in 29 patients (63.0%) and lesions with atypia in six patients (15.2%), without statistically significant difference of morphokinetic features, except of the association of clustered microcysts with proliferative dysplasia without atypia.

Conclusions. FCCs presenting as NME in DCE-MRI examination have several morphokinetic features suspicious of malignancy, therefore requiring biopsy (BI-RADS 4). Nonproliferative lesions, proliferative lesions without atypia and proliferative lesions with atypia predominantly share the same predefined DCE-MRI morphokinetic features.

Keywords: Breast; Magnetic Resonance Imaging; Fibrocystic changes