The outcome of the first 100 nasopharyngeal cancer patients in Thailand treated by Helical Tomotherapy

  • Imjai Chitapanarux 1Division of Radiation Oncology, Faculty of Medicine, Chiang Mai University, Chiang Mai, THAILAND 2Northern Thai Research Group of Radiation Oncology (NTRG-RO), Faculty of Medicine, Chiang Mai University, Chiang Mai, THAILAND
  • Wannapha Nobnop 1Division of Radiation Oncology, Faculty of Medicine, Chiang Mai University, Chiang Mai, THAILAND 2Northern Thai Research Group of Radiation Oncology (NTRG-RO), Faculty of Medicine, Chiang Mai University, Chiang Mai, THAILAND
  • Patumrat Sripan 1Division of Radiation Oncology, Faculty of Medicine, Chiang Mai University, Chiang Mai, THAILAND 2Northern Thai Research Group of Radiation Oncology (NTRG-RO), Faculty of Medicine, Chiang Mai University, Chiang Mai, THAILAND
  • Ausareeya Chumachote Division of Radiation Oncology, Faculty of Medicine, Chiang Mai University, Chiang Mai, THAILAND
  • Ekkasit Tharavichitkul 1Division of Radiation Oncology, Faculty of Medicine, Chiang Mai University, Chiang Mai, THAILAND 2Northern Thai Research Group of Radiation Oncology (NTRG-RO), Faculty of Medicine, Chiang Mai University, Chiang Mai, THAILAND
  • Somvilai Chakrabandhu 1Division of Radiation Oncology, Faculty of Medicine, Chiang Mai University, Chiang Mai, THAILAND 2Northern Thai Research Group of Radiation Oncology (NTRG-RO), Faculty of Medicine, Chiang Mai University, Chiang Mai, THAILAND
  • Pitchayaponne Klunklin 1Division of Radiation Oncology, Faculty of Medicine, Chiang Mai University, Chiang Mai, THAILAND 2Northern Thai Research Group of Radiation Oncology (NTRG-RO), Faculty of Medicine, Chiang Mai University, Chiang Mai, THAILAND
  • Wimrak Onchan 1Division of Radiation Oncology, Faculty of Medicine, Chiang Mai University, Chiang Mai, THAILAND 2Northern Thai Research Group of Radiation Oncology (NTRG-RO), Faculty of Medicine, Chiang Mai University, Chiang Mai, THAILAND
  • Bongkot Jia-Mahasap 1Division of Radiation Oncology, Faculty of Medicine, Chiang Mai University, Chiang Mai, THAILAND 2Northern Thai Research Group of Radiation Oncology (NTRG-RO), Faculty of Medicine, Chiang Mai University, Chiang Mai, THAILAND
  • Suwapim Janlaor Division of Radiation Oncology, Faculty of Medicine, Chiang Mai University, Chiang Mai, THAILAND
  • Patcharawadee Kayan Division of Radiation Oncology, Faculty of Medicine, Chiang Mai University, Chiang Mai, THAILAND
  • Patrinee Traisathit Department of Statistics, Faculty of Science, Chiang Mai University, Chiang Mai, THAILAND
  • Dirk Van Gestel Department of Radiation Oncology, Institut Jules Bordet, Université Libre de Bruxelles, BELGIUM

Abstract

pURPOSE: To analyze of two-year loco-regional failure free survival (LRFFS), distant metastasis free survival (DMFS), overall survival (OS), and toxicity outcomes of the first 100 nasopharyngeal carcinoma (NPC) patients in Thailand treated by Helical Tomotherapy (HT). MATERIALS AND METHODS: Between March 2012 and December 2015, 100 patients with non-metastatic NPC were treated by HT. All patients treated by platinum-based concurrent chemoradiotherapy (CCRT) and adjuvant or neo-adjuvant chemotherapy. RESULTS: The median age was 51 years (IQR: 42.5- 57.0). The mean ± SD of D95% of PTV70, 59.4 and 54 were 70.2 ± 0.5, 59.8 ± 0.6, and 54.3 ± 0.8, respectively. The mean ± SD of conformity index (CI), and homogeneity index (HI) were 0.89 ± 0.13 and 0.06 ± 0.07. Mean ± SD of D2 % of spinal cord and brainstem were 34.1 ± 4.4 and 53.3 ±6.3 Gy. Mean ± SD of D50 of contralateral and ipsilateral parotid gland were 28.4 ± 6.7 and 38.5 ± 11.2 Gy. At a median follow-up of 33 months (IQR: 25-41), the 2-year LRFFS, DMFS, OS were 94% (95%CI: 87- 98%), 96% (95%CI: 89-98%), and 99% (95%CI: 93-100%), respectively. Acute grade 3 dermatitis, pharyngoesophagitis, and mucositis occurred in 5%, 51%, and 37%, respectively. Late pharyngoesophagitis grade 0 and 1 were found in 98% and 2% of patients. Late xerostomia grade 0, 1 and 2 were found in 17%, 78% and 5%, respectively. CONCLUSIONS: HT offers good dosimetric performance and achieves excellent treatment outcome in NPC patients.

Published
2017-09-10
How to Cite
Chitapanarux, I., Nobnop, W., Sripan, P., Chumachote, A., Tharavichitkul, E., Chakrabandhu, S., Klunklin, P., Onchan, W., Jia-Mahasap, B., Janlaor, S., Kayan, P., Traisathit, P., & Van Gestel, D. (2017). The outcome of the first 100 nasopharyngeal cancer patients in Thailand treated by Helical Tomotherapy. Radiology and Oncology, 51(3). Retrieved from https://radioloncol.com/index.php/ro/article/view/2763
Section
Clinical oncology