INTERVAL CANCERS IN SLOVENIAN COLORECTAL CANCER SCREENING PROGRAMME AFTER FAECAL IMMUNOCHEMICAL TEST AND COMPARISON WITH SCREEN AND NON-RESPONDERS’ DETECTED CANCERS
Background. We are assessing the incidence and characteristics of interval cancers after faecal immunochemical occult blood test and calculating the test sensitivity in Slovenian colorectal cancer screening programme.
Patients and methods. The analysis included the population aged between 50 to 69 years, which was invited for screening between April 2011 and December 2012. The persons were monitored until the next foreseen invitation, in average for 2 years. The data on interval cancers and cancers in non-responders were obtained from Cancer Registry. Gender, age, years of schooling, the cancer site and stage were compared among three observed groups. We used the proportional incidence method to calculate the screening test sensitivity.
Results. Among 502,488 persons invited for screening cancers were detected; 493 after positive screening test, 79 interval cancers after negative screening test and 395 in non-responders. The proportion of interval cancers equalled 13.8%. Among the three observed groups cancers were more frequent in men (p = 0.009) and in persons aged 60+ years (p < 0.001). Comparing screen detected and cancers in non-responders with interval cancers more interval cancers were detected in persons with 10 years of schooling or more (p = 0.029 and p = 0.001), in stage III (p = 0.027) and IV (p < 0.001), and in right hemicolon (p < 0.001). Test sensitivity of faecal immunochemical test was 88.45%.
Conclusions.Interval cancersin Slovenian screening programme are detected in expected proportions as in similar programmes. Test sensitivity is among the highest when compared to similar programmes and is accomplished using two specimen samples test kit.
Key words: colorectal cancer screening, faecal immunochemical test, interval cancer, screen detected cancer, cancer in non-responders, test sensitivity