PERIOPERATIVE RADIOTHERAPY VERSUS SURGERY ALONE FOR RETROPERITONEAL SARCOMAS: A SYSTEMATIC REVIEW AND META-ANALYSIS

  • Alexandros Diamantis dr

Abstract

ABSTRACT

 

BACKGROUND

There is no clear evidence on whether radiotherapy(RT) reflects on a beneficial result in patients with retroperitoneal sarcomas(RPS).

METHODS

A systematic literature search was performed using PubMed, Scopus and CENTRAL databases. Data were retrieved from published comparatives studies in patients with RPS undergoing surgery alone or RT plus surgery. The primary endpoints were the 5-year OS and the median OS. The secondary endpoints were the recurrence-free survival(RFS) and the R0-resection rate. Continuous outcomes were calculated by means of weighted mean difference(WMD).

RESULTS

Ten out of 374 articles were included in the quantitative synthesis. The median OS and the 5-year survival, were significantly increased in patients treated with RT and surgery, compared to patients treated with surgery alone(p< 0.00001, p< 0.001).  Median RFS was significantly increased in patients treated with either preoperative (p< 0.001) or postoperative(p =0.001) RT compared to patients that underwent surgery alone. Finally, median R0-resection rate was similar between the two groups(p=0.56).

CONCLUSION

RT along with radical surgery could be the standard of care in at least a subgroup of patients with RPS.

Published
2020-03-25
How to Cite
Diamantis, A. (2020). PERIOPERATIVE RADIOTHERAPY VERSUS SURGERY ALONE FOR RETROPERITONEAL SARCOMAS: A SYSTEMATIC REVIEW AND META-ANALYSIS. Radiology and Oncology, 54(1), 14-21. Retrieved from https://radioloncol.com/index.php/ro/article/view/3379
Section
Review