The Performance of the Xpert BC Monitor Test and Voided Urinary Cytology in the Follow-Up of Urinary Bladder Tumors

  • Tomaž Smrkolj Department of urology, University medical center Ljubljana, Slovenia
  • Urška Čegovnik Primožič
  • Teja Fabjan
  • Saša Šterpin
  • Josko Osredkar

Abstract

Background. Cystoscopy in complement with urinary cytology represents the gold standard for the follow-up of patients with urinary bladder tumors. The aim of the study was to evaluate the performance of the Xpert BC Monitor test and voided urinary cytology in the follow-up of bladder tumors.

Methods. The Xpert BC Monitor test was performed on stabilized voided urine and voided urinary cytology was performed on urine samples. The results were compared to cystoscopic findings and histopathological results after transurethral resection of the bladder lesion.

Results. For the prediction of malignant histopathological result sensitivity, the specificity and negative predictive value were 76.9 %, 97.5 %, and 93.0 % respectively for the Xpert BC Monitor test and 46.2 %, 97.5 %, and 85.1 % for voided urinary cytology. For the prediction of suspicious or positive cystoscopic finding sensitivity, the specificity and negative predictive value were 75.0 %, 95.2 %, and 93.0 % respectively for the Xpert BC Monitor test and 41.7 %, 97.6 %, and 85.4 % for voided urinary cytology. The sensitivities for PUNLMP, low- and high-grade tumors were 0.0 %, 66.7 % and 100.0 % for the Xpert BC Monitor test respectively and 0.0 %, 66.7 % and 42.9 % for voided urinary cytology.

Conclusions. The Xpert BC Monitor test showed significantly higher overall sensitivity and negative predictive value than VUC and could be used to increase the recommended follow-up cystoscopy time intervals. Complementing the Xpert BC Monitor test and voided urinary cytology does not improve performance in comparison to the Xpert BC Monitor test alone.

Published
2021-04-27
How to Cite
Smrkolj, T., Čegovnik Primožič, U., Fabjan, T., Šterpin, S., & Osredkar, J. (2021). The Performance of the Xpert BC Monitor Test and Voided Urinary Cytology in the Follow-Up of Urinary Bladder Tumors. Radiology and Oncology, 55(2), 196-202. Retrieved from https://radioloncol.com/index.php/ro/article/view/3560
Section
Clinical oncology