Study of Correlations between CT Properties of Retrieved Cerebral Thrombi with Treatment Outcome of Stroke Patients
CT of cerebral thrombi
Background. All the patients with Stroke as a part of standard treatment protocol are directed to pre- and post-contrast brain CT scan. The purpose of this scan is mainly to determine the type of Stroke, hemorrhagic or ischemic, and to locate the occlusion in case of the Ischemic Stroke, while the CT information about the thrombus causing the Stroke is usually overlooked or considered not important. The aim of this study is to test whether there is some value of the information on the thrombus given by CT images.
Patients and methods. There were 25 patients included in the study, diagnosed with ischemic stroke in the MCA segment. In all patients, Thrombolysis was not successful and the mechanical recanalization was needed. The retrieved thrombi were also analyzed histologically for the determination of RBC proportion. CT of the MCA segment was analyzed for average HU value and its variability both in the occluded section and the symmetrical normal site. These CT parameters were then statistically studied for the possible correlations with different clinical, histological and procedure parameters using the Linear Regression and the Pearson correlation coefficient.
Results. Relevant positive correlations were found between average HU value of thrombus and outcome modified Rankin Scale (mRS), initial mRS, number of passes with thrombectomy device as well as RBC proportion.
Conclusions. Results of the present study confirmed that measured HU values in CT images of the cerebral thrombi in addition to the clinical parameters can help in the prediction of treatment success and possible treatment complications.
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