Radiological assessment of skeletal muscle index and myosteatosis and their impact postoperative outcomes after liver transplantation
Introduction. Liver transplantation offers curative treatment to patients with acute and chronic end-stage liver disease. The impact of nutritional status on postoperative outcomes after liver transplantation remains poorly understood. The present study investigated the predictive value of radiologically assessed skeletal muscle index (SMI) and myosteatosis (MI) on postoperative outcomes.
Material and methods Data of 138 adult patient patients who underwent their first orthotopic liver transplantation were retrospectively analysed. SMI and MI in computer tomography (CT) scan at the third lumbar vertebra level were calculated. Results were analyzed for the length of hospitalisation and postoperative outcomes.
Results In 63% of male and 28.9% of female recipients, low SMI was found. High MI was found in 45(32.6%) patients. Male patients with high SMI had longer ICU stay (P <0.025). Low SMI had no influence on ICU stay in female patients (P =0.544), length of hospitalisation (male, P >0.05; female, P =0,843), postoperative complication rates (males, P =0,883; females, P =0.113), infection rate (males, P =0.293, females, P =0.285) and graft rejection (males, P =0.875; females, P =0.135). The presence of MI did not influence ICU stay (P =0.161), hospitalization (P =0.771), postoperative complication rates (P =0.467), infection rate (P = 0.173) or graft rejection rate (P =0.173).
Conclusion In our study, changes in body composition of liver transplant recipients observed with SMI and MI had no impact on postoperative course after liver transplantation. Standardization and uniformly accepted definitions and cut-off points are crucial to producing reliable data in the future
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Copyright (c) 2023 Miha Petrič, Taja Jordan, Popuri Karteek , Sabina Ličen, Blaž Trotovšek, Aleš Tomažič
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