Assessment of Short-term Effect of Platelet-rich Plasma Treatment of Tendinosis using Texture Analysis of Ultrasound Images

Authors

  • Karlo Pintarić assistant
  • Vladka Salapura associate professor
  • Žiga Snoj assistant professor
  • Andrej Vovk
  • Mojca Božič Mijovski assistant professor
  • Jernej Vidmar assistant professor

Abstract

Background: Computer-aided diagnosis (i.e., texture analyses) tools are becoming increasingly beneficial methods to monitor subtle tissue changes. The aim of this pilot study was to investigate short-term effect of PRP treatment in supraspinatus and common extensor of the forearm tendinosis by using texture analysis of US images as well as by clinical questionnaires.

Patients and methods: Thirteen patients (7 male and 6 female, age 36 –-60 years, mean age 51.2 ± 5.2) were followed after US guided PRP treatment for tendinosis of two tendons (9 patients with lateral epicondylitis and 4 with supraspinatus tendinosis). Clinical and US assessment was performed prior to as well as 3 months after PRP treatment with validated clinical questionnaires. Tissue response in tendons was assessed by using gray level run length matrix method (GLRLM) of US images.

Results: All patients improved of tendinosis symptoms after PRP treatment according to clinical questionnaires. Almost all GLRLM features were statistically improved 3 months after PRP treatment. glrlm_LRLGLE revealed the best moderate positive and statistically significant correlation after PRP (r = 0.4373, p = 0.0255), followed by glrlm_LGLRE (r = 0.3877, p = 0.05).

Conclusions: Texture analysis of tendinosis US images is a useful quantitative method for the assessment of tendon remodeling after minimally invasive PRP treatment. GLRLM features have the potential to become useful imaging biomarkers to monitor spatial and time limited tissue response after PRP, however larger studies with similar protocols are needed.

 

Keywords: texture analysis, tendinosis, platelet-rich plasma, ultrasonography

Author Biographies

Vladka Salapura, associate professor

Institute of Radiology, University Medical center Ljubljana, Ljubljana, Slovenia.

Žiga Snoj, assistant professor

Institute of Radiology, University Medical center Ljubljana, Ljubljana, Slovenia.

Andrej Vovk

Center of Clinical Physiology, Medical faculty, University of Ljubljana, Ljubljana, Slovenia

Mojca Božič Mijovski , assistant professor

Laboratory for Haemostasis and Thrombosis, University Medical Centre, Ljubljana, Slovenia.

Jernej Vidmar, assistant professor

Institute of Physiology, Medical faculty, University of Ljubljana, Ljubljana, Slovenia

Institute of Radiology, University Medical center Ljubljana, Ljubljana, Slovenia

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Published

2023-11-27

How to Cite

Pintarić, K., Salapura, V., Snoj, Žiga, Vovk, A., Božič Mijovski , M., & Vidmar, J. (2023). Assessment of Short-term Effect of Platelet-rich Plasma Treatment of Tendinosis using Texture Analysis of Ultrasound Images. Radiology and Oncology, 57(4), 465–472. Retrieved from https://radioloncol.com/index.php/ro/article/view/4126

Issue

Section

Radiology