Quantitative assessment of bone marrow infiltration and characterization of tumor burden using dual-layer spectral CT in patients with Multiple myeloma

Quantitative assessment of tumor burden using DLCT in Multiple myeloma

Abstract

Objectives To evaluate whether virtual calcium subtraction (VNCa) image extracted from dual-layer spectral CT could estimate bone marrow (BM) infiltration with MRI as the reference standard and characterize tumor burden in patients with Multiple myeloma (MM).

Methods Forty-seven patients with newly diagnosed MM were retrospectively enrolled. They had undergone whole-body low-dose DLCT and whole-body MRI within one week. VNCa images with CaSupp indices ranging from 25 to 95 at an interval of 10 and ADC maps were quantitatively analyzed on vertebral bodies L1-L5 at the central slice of images. The optimal combination was selected by correlation analysis between CT numbers and ADC values. Then, it was used to characterize tumor burden by correlation analysis and receiver operating characteristic (ROC) curves analysis, including plasma cell infiltration rate (PCIR), high serum-free light chains (SFLC) ratio and the high-risk cytogenetic (HRC) status.

Results The most significant quantitative correlation between CT numbers of VNCa images and ADC values could be found at CaSupp index 85 for averaged L1-L5 (r = 0.612, p < 0.001). It allowed quantitative evaluation of PCIR (r = 0.835, p < 0.001). It could also anticipate high SFLC ratio and the HRC status with AUC of 0.876 and 0.760, respectively.

Conclusions The VNCa measurements of averaged L1-L5 showed the highest correlation with ADC at CaSupp index 85. It could therefore be used as additional imaging biomarker for non-invasive assessment of tumor burden if ADC is not feasible.