Role of diffusion-weighted imag-ing in response prediction and evaluation after high dose rate brachytherapy in patients with colorectal liver metastases

Abstract

Background. To assess the role of diffusion-weighted imaging (DWI) to evaluate treatment response in patients with liver metastases of colorectal cancer.

Patients and methods. / Materials and methods. In this retrospective, observational cohort study, we included 19 patients with 18 responding metastases (R-Mets, follow-up at least one year) and 11 non-responding metastases (NR-Mets, local tumor recurrence within one year) who were treated with HDR-BT and underwent pre- and post-interventional MRI. DWI (qualitatively, ADCmean, ADCmin, intraindividual change of ADCmean and ADCmin) were evaluated and compared between pre-interventional MRI, 1. follow-up after 3 months and 2. follow-up at the time of the local tumor recurrence (in NR-Mets, mean: 284+/-122 d) or after 12 months (in R-Mets, mean: 387+/-64 d). Sensitivity, specificity, positive predictive values (PPVs), and negative predictive values (NPVs) for detection of local tumor recurrence were calculated on second follow up, evaluating (1) DWI images only, and (2) DWI with Gd-enhanced T1-weighted images on hepatobiliary phase (CE T1w hb)

Results. ADCmean significantly increased 3 months after HDR-BT in both groups (R-Mets: 1.48 ± 0.44 and NR-Mets: 1.49 ± 0.19 x 10-3 mm²/s, p<0.0001 and p=0.01), however, intraindividual change of ADCmean (175% vs.127%, p=0.03)) and ADCmin values (0.44 ± 0.24 to 0.82 ± 0.58 x 10−3 mm2/s) significantly increased only in R-Mets (p<0.0001 and p<0.001). ADCmin was significant higher in R-Mets compared to NR-Mets on first follow-up (p=0.04).

Sensitivity (1 vs. 0.72), specificity (0.94 vs. 0.72), PPV (0.91 vs. 0.61) and NPV (1 vs. 0.81) could be improved by combining DWI with CET1w hb compared to DWI only.

Conclusions. DW-MRI seems to be helpful in the qualitative and quantitative evaluation of treatment response after HDR-BT of colorectal metastases in the liver.