Liver volumetry improves evaluation of treatment response to hepatic artery infusion chemotherapy in uveal melanoma patients with liver metastases

Authors

  • Sebastian Zensen University Hospital Essen - Institute of Diagnostic and Interventional Radiology and Neuroradiology
  • Hannah L. Steinberg-Vorhoff
  • Aleksandar Milosevic
  • Heike Richly
  • Jens T. Siveke
  • Marcel Opitz
  • Johannes Haubold
  • Yan Li
  • Michael Forsting
  • Benedikt Michael Schaarschmidt

Abstract

Background . In uveal melanoma patients, short-term evaluation of treatment response to hepatic artery infusion chemotherapy (HAIC) using the Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 criteria is challenging due to the diffuse metastatic spread. As liver enlargement can frequently be observed, this study aims to compare RECIST 1.1 and liver volumetry (LV) for the evaluation of HAIC treatment response.

 

Patients and methods. / Materials and methods. .Treatment response was evaluated in 143 patients (mean age 65.1±10.9y, 54% female) treated by HAIC by RECIST 1.1 and LV on CT imaging performed before and after HAIC. In LV, different increases in liver volume were evaluated to set an effective threshold to distinguish between stable disease (SD) and progressive disease (PD). Overall survival (OS) was calculated as the time from first HAIC to patient death using Kaplan-Meier test and multivariate analysis was performed for RECIST 1.1 and LV.

 

Results. . In the overall population, median OS (mOS) was 13.5 months (95% CI 11.2-15.8 months). In LV, a threshold of 10% increase in liver volume was suited to identify patients with significantly reduced OS (SD: 103/143 patients, mOS 15.9 months; PD: 40/143 patients, 6.6 months; p<0.001). Compared to RECIST 1.1, LV is the only significant prognostic factor that can identify a decreased OS..

 

Conclusions. In uveal melanoma patients with liver metastases, LV with a threshold for liver volume increase of 10% is suitable to evaluate treatment response and can be used as a valuable add-on or even alternative to RECIST 1.1.

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Published

2024-11-26

How to Cite

Zensen, S., Steinberg-Vorhoff, H. L., Milosevic, A., Richly, H., Siveke, J. T., Opitz, M., … Schaarschmidt, B. M. (2024). Liver volumetry improves evaluation of treatment response to hepatic artery infusion chemotherapy in uveal melanoma patients with liver metastases. Radiology and Oncology, 58(4), 509–516. Retrieved from https://radioloncol.com/index.php/ro/article/view/4458

Issue

Section

Radiology