Patient survival after resection of skeletal metastases and endoprosthetic reconstruction: A nation-wide cohort study

Abstract

Introduction: The aim of this nation-wide 2009-2021 cohort study was to analyze postoperative survival of patients with resected skeletal metastases and endoprosthetic reconstruction in comparison to sarcoma patients and non-oncological reconstructions.

Methods:  A nation-wide cohort of 144 consecutive patients with tumor endoprosthetic reconstructions (32 resected metastases, 73 resected sarcomas, 39 non-oncological) was stratified into histopathological groups according to the 2013-SPRING prediction model, their survival was analyzed with the Kaplan-Meier method and Cox regression.

Results: The observed patient survival rates after wide resection of fast/moderate/slow growing metastases were 25/55/88 % at 2 years and 10/30/83 % at 5 years, while in sarcomas the observed survival rates were 80 % at 2 years and 69 % at 5 years. Estimated mean postoperative survival after resection of skeletal metastases was significantly shorter in comparison to sarcomas (4.6 years vs. 9.1 years, log-rank p < 0.001). Predictors of worse patient survival included higher age, pathologic fracture or >1 metastasis, diagnostic group fast-growing metastases and higher preoperative CRP.

Conclusion: Wide resection and endoprosthetic reconstruction offers a reliable solution in selected patients with skeletal metastases. Higher age, fast-growing metastases (bladder, colorectal, hepatocellular, lung, malignant melanoma, unknown), pathologic fracture or >1 metastasis and elevated CRP predict shorter patient survival and may represent a relative contraindication in this regard.