@article{Gültekin_2017, title={Protective/Restorative Role of the ADMSC on the RAI-induced Salivary Gland Damage in Rats}, volume={51}, url={https://radioloncol.com/index.php/ro/article/view/2744}, abstractNote={<p><strong>Objective:</strong> We evaluated protective/regenerative effects of adipose tissue-derived mesenchymal stem cells (ADMSC) on RAI-induced salivary gland damage in rats.  </p><p><strong>Methods:</strong> Study population consists of controls (n:6) and treatments (n:54); RAI (Group 1), ADMSC (Group 2), amifostine (Group 3), RAI/amifostine (Group 4), RAI/ADMSC concomitantly (Group 5) or after 48 h (Group 6). We used light microscopy (LM), transmission electron microscopy (TEM) and salivary gland scintigraphy (SGS), and analyzed data statistically.</p><p><strong>Results:</strong> We observed the homing of ADMSC in salivary glands at 1<sup>st</sup> month by LM. Necrosis, periductal fibrosis, periductal sclerosis, vascular sclerosis and a total sum score were statistically affected by RAI exposure (<em>P</em><0.05). In intragroup comparisons LM during 1<sup>st</sup> and 6<sup>th</sup> month revealed statistically significant improvements for Group 6 (<em>P</em><0.05) but not for Groups 4/5. Intergroup comparisons of the total score showed Groups 4/5 in 1<sup>st</sup> month and Group 6 in 6<sup>th</sup> month had the lowest value. TEM showed vacuolization, edema, and fibrosis in 1<sup>st</sup> month and an improvement in damage in 6<sup>th</sup> month for Groups 5/6. SGSs revealed significant differences for Smax (<em>P</em><strong>=</strong>0.007) and G/BGmax (<em>P</em><strong>=</strong>0.005) in 1<sup>st</sup> month, for G/BGmax (<em>P</em>=0.005), Smax (<em>P</em>=0.005) and Tmax/Tmin (<em>P</em>=0.027) in 6<sup>th</sup> month. Between 1<sup>st</sup> and 6<sup>th</sup> month scans there were differences for Smax and G/BGmax (<em>P</em>=0.04), but not for Tmax/Tmin (p>0,05). We observed a prominent deterioration in gland function in-group 1, whereas, mildly to moderate deteriorations in protective treatment groups.</p><p><strong>Conclusion:</strong> Our results indicate that ADMSC may play a promising role as the protective/regenerative agent against RAI-induced salivary gland dysfunction.</p>}, number={3}, journal={Radiology and Oncology}, author={Gültekin, Salih Sinan}, year={2017}, month={Sep.} }