TY - JOUR AU - Milosevic, Zorica AU - Nadrljanski, Mirjan AU - Milovanovic, Zorka AU - Gusic, Nina AU - Vucicevic, Slavko AU - Radulovic, Olga PY - 2017/06/07 Y2 - 2024/03/29 TI - Breast Dynamic Contrast Enhanced MRI: Fibrocystic Changes Presenting as a Non-Mass Enhancement Mimicking Malignancy JF - Radiology and Oncology JA - Radiol Oncol VL - 51 IS - 2 SE - Radiology DO - UR - https://radioloncol.com/index.php/ro/article/view/2708 SP - AB - <p>Background. We aimed to analyze the morphokinetic features of breast fibrocystic changes (nonproliferative lesions, proliferative lesions without atypia and proliferative lesions with atypia) presenting as a non-mass enhancement (NME) in dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) examination.</p> <p>Patients and methods. Forty-six patients with histologically proved fibrocystic changes (FCCs) were retrospectively reviewed, according to Breast Imaging Reporting and Data System (BI-RADS) lexicon. Prior to DCE-MRI examination, a unilateral breast lesion suspicious of malignancy was detected clinically, on mammography or breast ultrasonography.</p> <p>Results. The predominant features of FCCs presenting as NME in DCE-MRI examination were: unilateral regional or diffuse distribution (in 35 patients or 76.1%), heterogeneous or clumped internal pattern of enhancement (in 36 patients or 78.3%), plateau time-intensity curve (in 25 patients or 54.3%), moderate or fast wash-in (in 31 patients or 67.4%). Nonproliferative lesions were found in 11 patients (23.9%), proliferative lesions without atypia in 29 patients (63.0%) and lesions with atypia in six patients (15.2%), without statistically significant difference of morphokinetic features, except of the association of clustered microcysts with proliferative dysplasia without atypia.</p> <p>Conclusions. FCCs presenting as NME in DCE-MRI examination have several morphokinetic features suspicious of malignancy, therefore requiring biopsy (BI-RADS 4). Nonproliferative lesions, proliferative lesions without atypia and proliferative lesions with atypia predominantly share the same predefined DCE-MRI morphokinetic features.</p> <p>Keywords: Breast; Magnetic Resonance Imaging; Fibrocystic changes</p> ER -