Micro RNAs and long non-coding RNAs: prospects in diagnostics and therapy of cancer

  • Damjan Glavac Department of Molecular Genetics, Institute of Pathology, Medical Faulty, University of Ljubljana, Korytkova 2, SI-1000 Ljubljana, Slovenia
  • Nina Hauptman

Abstract

Background. Non-coding RNAs (ncRNAs) are key regulatory molecules in cellular processes, and are potential biomarkers in many diseases. Currently, microRNAs and long non-coding RNAs are being pursued as diagnostic and prognostic biomarkers, and as therapeutic tools in cancer, since their expression profiling is able to distinguish different cancer types and classify their sub-types.

Conclusions. There are numerous studies confirming involvement of ncRNAs in cancer initiation, development and progression, but have only been recently identified as new diagnostic and prognostic tools. This can be beneficial in future medical cancer treatment options, since ncRNAs are natural antisense interactors included in regulation of many genes connected to survival and proliferation. Research is directed in development of useful markers for diagnosis and prognosis in cancer and in developing new RNA-based cancer therapies, of which some are already in clinical trials.

Author Biography

Damjan Glavac, Department of Molecular Genetics, Institute of Pathology, Medical Faulty, University of Ljubljana, Korytkova 2, SI-1000 Ljubljana, Slovenia
Published
2015-02-23
How to Cite
Glavac, D., & Hauptman, N. (2015). Micro RNAs and long non-coding RNAs: prospects in diagnostics and therapy of cancer. Radiology and Oncology, 47(4). Retrieved from https://radioloncol.com/index.php/ro/article/view/1990
Section
Review