Premalignant gastric lesions in patients included in National colorectal cancer screening

  • Bojan Tepeš
  • Maja Šeruga
  • Miroslav Vujasinovič
  • Dejan Urlep
  • Ljiljana Ljepovič
  • Nataša Brglez Jurečič
  • Alenka Forte
  • Anita Kek Ljubec
  • Miha Škvarč

Abstract

 

Background. Gastric cancer is the fifth most common malignancy in the world with almost one million new cases annually. Helicobacter pylori infection cause 89% of all gastric cancers. Premalignant lesions (atrophy and intestinal metaplasia) develop after several decades of inflammation. Secondary prevention with gastroscopy is possible, but it is costly and has a low compliance rate. Alternative procedures like serology testings for pepsinogen I and II and pepsinogen I/II ratio are available to select patients for surveillance gastroscopies.

 

Patients and methods. In seven outpatient endoscopic units, 288 patients (154 men; 53.5%), average age 60.68 years, tested positive in National colorectal cancer screenning programme  SVIT, were included in the study.Gastropanel (BioHit, Finland) was used as a serologic biopsy method.

 

Results. We found 24 patients (12 men, mean age 63.7 years ) with pepsinogen pepsinogen I/II < 3 and/or pepsinogen I < 30µg/L). Premalignant changes were found on gastric  biopsies  in 21 patients (7.3% incidence). OLGIM (Operative Link on Gastric Intestinal Metaplasia Assessment) > 1 was found in 20 patients; OLGA (Operative Link for Gastritis Assessment) > 1 was found in 19 patients. Combined accuracy for preneoplastic lesions in Gastropanel positive patients was 87.5%. H. pylori seropositivity was found in 219 patients (76%). Only 24% of our population had normal results.

 

ConclusionGastropanel test has proven to be a reliable non-invasive test for advanced gastric preneoplastic lesions that can select patients for further gastroscopy. We found high  H. pylori seropositivity  in older age groups in Slovenia .

 

Key words: Gastropanel, Helicobacer pylori, atrophy, intestinal metaplasia, gastric cancer

 

Published
2018-02-21
How to Cite
Tepeš, B., Šeruga, M., Vujasinovič, M., Urlep, D., Ljepovič, L., Brglez Jurečič, N., Forte, A., Kek Ljubec, A., & Škvarč, M. (2018). Premalignant gastric lesions in patients included in National colorectal cancer screening. Radiology and Oncology, 52(1). Retrieved from https://radioloncol.com/index.php/ro/article/view/2918
Section
Clinical oncology